• br Materials and methods br Results br Discussion It was

  2022-01-20

  

  Materials and methods Results Discussion It was previously shown that heterologous DNA vaccines composed of fused cDNA fragments encoding chimeric NH2-terminal human HER2 and COOH-terminal rat neu sequences stimulated stronger antibody responses and protective antitumor immunity than either

• In the previous study concerning HO mediated

  2022-01-20

  

  In the previous study concerning HO-1-mediated inhibtion of HCV replication, the mechanism underlying IFN-α/β indcuction by HO-1 involved in HO-1-catalyzed heme metabolic product, biliverdin (Zhu et al., 2010; Lehmann et al., 2010). However, in the present study SnPP, an inhibitor of HO-1 enzymatic

• br Introduction Activation of the

  2022-01-19

  

  Introduction Activation of the lipid sensing receptor, GPR55, by lysophosphatidyl inositol (LPI) has been well documented, and implicated in endocannabinoid signaling [1]. Intracellular events resulting from GPR55 activation include; enhanced β-arrestin activity, calcium mobilization and ERK1/2 p

• br Acknowledgments br Introduction Myelin one

  2022-01-19

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the lomitapide australia of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cell

• br Discovery of GPR A The murine

  2022-01-19

  

  Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t

• Generally speaking the regulation of

  2022-01-19

  

  Generally speaking, the regulation of GnIH on gonadotropins synthesis and release, although controversial, could be direct and/or indirect via GnRH, among others peptides. In this sense, different scenarios have been reported in vertebrates. In mammalian and avian species, GnIH fibers reach the medi

• It is widely acknowledged that CpG methylation of the promot

  2022-01-19

  

  It is widely acknowledged that CpG methylation of the promoter regions of some genes plays an important regulatory role in transcriptional regulation and in the establishment and maintenance of cell type-specific gene expression (Li, 2002, Jaenisch and Bird, 2003). This study obtained multiple lines

• It is important to underline that although

  2022-01-19

  

  It is important to underline that SQ 22536 although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food intake and r

• br Acknowledgments br Introduction When human red blood cell

  2022-01-19

  

  Acknowledgments Introduction When human red blood cell (hRBC) membranes are depolarized, either as intact 65 0 suspended in depolarizing (low Cl−) Ringers or under voltage clamp conditions using excised inside-out patches, they respond by opening a nonselective voltage-dependent cation (NSVDC

• br Promotion of GLS expression Glutamine metabolism is

  2022-01-19

  

  Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino Chlorprothixene starvation [72]. The first step of glutamine catabolism is its conversion to glutamate

• The lower number of samples

  2022-01-19

  

  The lower number of samples tested for the comparison between cobas 4800 HIV-1 and RealTime HIV-1, especially at or below 50 copies/mL (Table 6), could limit our ability to discern a difference in the ability of the various assays to identify patients with virological failure. However, the 95% CI ar

• In autoimmune diseases lymphocytes penetrate into the

  2022-01-18

  

  In autoimmune diseases, lymphocytes penetrate into the inflammatory lesions of tissues, where it is prominently hypoxic or even anoxic, and utilize glycolysis for an energy supply after activation or under hypoxia (Sitkovsky and Lukashev, 2005; Palazon et al., 2014), which is modulated by the oxygen

• Etoposide VP a semisynthetic podophyllotoxin derivative agen

  2022-01-18

  

  Etoposide (VP-16), a semisynthetic podophyllotoxin derivative agent, is widely used as a chemotherapic treatment for many cancers (Hande, 1998). VP-16 has been known that its activity is mediated by the interaction with topoisomerase II (an ATP-dependent nuclear enzyme) which regulates DNA topology

• G protein coupled receptors GPCRs

  2022-01-18

  

  G-protein coupled receptors (GPCRs) constitute a large family of 7 trans-membrane-spanning proteins that activate internal signal transduction cascades through binding to different ligands including neurotransmitters, peptides, and lipids [7]. This family of receptors has therapeutic potentials in t

• br Discussion Recent progresses in osteoblast biology

  2022-01-18

  

  Discussion Recent progresses in osteoblast biology reveal that aerobic glycolysis was the main pathway to supply energy and materials that need by osteoblast differentiation [3]. In current study, we showed that LA enhanced the effect of PTH on osteblast differentiation and revealed an unrecogniz

16245 records 522/1083 page Previous Next First page 上5页 521522523524525 下5页 Last page