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In conclusion a series of new carboxamido
2021-12-20
In conclusion, a series of new 3-carboxamido-5-aryl-isoxazoles was designed, synthesized and screened for their inhibitory potency against FAAH. Their cytotoxicity was determined and their lipophilicity was calculated. Compounds bearing a 3-substituted biphenyl moiety with high Log values displayed
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While IN inhibitors are a relatively new addition to the
2021-12-20
While IN inhibitors are a relatively new addition to the clinician's palette of drugs to formulate HAART regimes, resistance to both INSTIs and LEDGINs has been observed. For example, even within Australia where it is estimated that 25,313 people are currently living with HIV and the infection rate
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Smoking is strongly and consistently associated with periodo
2021-12-20
Smoking is strongly and consistently associated with periodontitis in the general population. In our study we detected a similar pattern in patients with HIV infection: smokers had a higher DPSI score compared to non-smokers. The exact cause of smoking as a risk factor for periodontitis in the gener
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Accompanied with apoptosis other ways
2021-12-20
Accompanied with apoptosis, other ways of neuronal death also occur in ischemic ras inhibitor due to the impairment of mitochondrial homeostasis [16]. Oxidative DNA damage activates poly (ADP-ribose) polymerase 1 (PARP-1) to induce regulated necrosis, referred to as parthanatos, in the brain [17]. O
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12198 synthesis The occurrence of naturally HCV NS resistanc
2021-12-20
The occurrence of naturally HCV NS3 resistance-associated substitutions (RAS) affects virological outcome of DAA-based combination therapies [14], [15], [16], [17], [18], [19]. For the majority of NS3 protease inhibitors the frequency of natural occurrence of single RASs in HCV genotype 1-infected p
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br Soluble guanylyl cyclase nitric oxide and nitric
2021-12-20
Soluble guanylyl cyclase, nitric oxide and nitric oxide synthase The primary and best-studied endogenous activator of soluble guanylyl cyclase (sGC) is nitric oxide (NO), which was originally describe as endothelium-derived relaxing factor for its potent ability to relax blood vessels in response
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br Materials and methods br Results br Discussion
2021-12-20
Materials and methods Results Discussion In this report, we have analyzed the function of an orphan GPCR, and GPR84, using genetically-deficient mice. The expression of GPR84 in the T and ACY-241 in the spleen prompted us to examine the functional responses of these cells under in vitro an
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Our data for glucose and insulin tolerance tests indicate
2021-12-20
Our data for glucose and insulin tolerance tests indicate that niacin-induced hyperglycemia is proportional to the degree of insulin resistance induced, implying that there is deterioration in islet function with niacin treatment (McCulloch et al., 1991). In this regard, we have demonstrated, for th
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The third generation cephalosporin antibiotics can cross the
2021-12-20
The third-generation cephalosporin 5-Formyl-UTP receptor can cross the blood brain barrier (BBB) [94]. In addition, several studies have shown that CEF can also cross the BBB [95,96] through a facilitated transport process [95]. However, due to the fact that CEF has poor bioavailability when taken
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br Declaration of interest br Acknowledgments This work was
2021-12-20
Declaration of interest Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 31471615), the Introduction of Talent Research Start-up Fund of Anhui Polytechnic University (No. 2017YQQ017) and the Pre-research Project of National Natural Sc
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FIPI receptor br Discussion RBCs possess a much
2021-12-20
Discussion RBCs possess a much simpler composition and structure than other eukaryotic FIPI receptor and can therefore serve as a convenient system on which to study how cell functioning relates to the molecular and supramolecular properties of its constituents. The model developed in this work i
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br Results and discussion br
2021-12-20
Results and discussion Conclusion In conclusion, twenty-one 4-monocyclic aryl-5-carbamoyl-3-isoxazolols have been synthesized and evaluated for their antagonistic activities against housefly and common cutworm GABARs expressed in Xenopus oocytes. The TEVC results indicated that PS341 sale sev
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Introduction galactosidase d galactoside galactohydrolase
2021-12-20
Introduction β-galactosidase (β-d-galactoside galactohydrolase or lactase; EC 3.2.1.23) is an important type of glycoside hydrolase that can catalyze the conversion of lactose to glycoprotein inhibitors and galactose. Furthermore, it can also catalyze transglycosylation reactions, which are usuall
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The physicochemical properties of the prodrugs provided impo
2021-12-20
The physicochemical properties of the prodrugs provided important clues for understanding a broad range of inhibitory activities in the cell assays (Table 2). Some physicochemical properties are useful in predicting drug absorption. Considering Lipinski’s rules and the polar surface area (PSA),l-ala
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Fatty acid amide hydrolase FAAH is a
2021-12-20
Fatty BMS 309403 amide hydrolase (FAAH) is a membrane-bound enzyme which releases arachidonic acid and ethanolamine by breaking amide bond of AEA. It also controls the cellular uptake of AEA, by creating and maintaining an inward concentration gradient leading to AEA-facilitated diffusion via a spe
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