Our results are consistent with previous findings in other m
Our results are consistent with previous findings in other malignancies. Functional assays revealed that ectopic expression of UCA1 promoted cell proliferation and/or reduced cell apoptosis in non-small cell lung cancer , breast cancer , colorectal cancer , and renal cell carcinoma . Knockdown of UCA1 impaired cell invasion or migration ability in breast cancer , esophageal squamous cell carcinoma , hepatocellular carcinoma, ovarian cancer , and melanoma . UCA1 also decreased chemosensitivity in colorectal cancer, ovarian cancer , and phospholipase c inhibitor cancer . Clinical investigation demonstrated that UCA1 overexpression was related to lymph node metastasis and advanced FIGO stage in ovarian cancer . Increased UCA1 expression correlated with worse differentiation, large tumor size, deep local invasion, and advanced TNM stage in gastric cancer . Further, high UCA1 expression was an unfavorable prognostic factor for overall survival of patients with esophageal squamous cell carcinoma , gastric cancer , colorectal cancer , hepatocellular carcinoma , and epithelial ovarian cancer . Taken together, these research indicated the oncogenic functions of UCA1 in human cancers and suggested a potential application for UCA1 in molecular targeted therapy.
Conflicts of interest