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  • Main Text These are exciting times for stem


    Main Text These are exciting times for stem cell research and its application to human health. Unprecedented opportunities now exist to harness the power of stem amantadine hcl to understand and treat disease. We continue to learn more about the potential of stem cells of many different types to contribute to the body\'s innate renewal and repair processes. We are discovering how to drive the differentiation of patient-specific pluripotent stem cells into many different tissue types to study disease in the petri dish. We can change cell fate in a controlled manner both in culture and inside the body, and, importantly, we are seeing a growing number of novel stem cell-related therapies moving to clinical trials. I truly believe that stem cell research will transform the treatment of many devastating diseases and injuries in the years ahead. The launch of this journal, Stem Cell Reports, by the International Society for Stem Cell Research (ISSCR) in 2013 was an exciting time for our organization and the stem cell community. By providing a high visibility, open access journal dedicated to sharing the latest findings in all areas of stem cell research, we have been able to provide increased access to advances and trends within our field to a broad audience. Stem Cell Reports is exceeding our expectations, capturing the attention of the research community as well as the scientific and mainstream media. With this issue, June 2014, we are both celebrating our first anniversary edition of Stem Cell Reports and deepening our commitment to fostering the exchange and dissemination of the highest quality information and ideas relating to stem cell research and increasing the translation of this knowledge into improved human health. The ISSCR aims to build trustworthiness within the stem cell research and clinical community: setting expectations for professional integrity and responsibility; providing guidance for rigorous standards for stem cell research and clinical application; considering ethical, legal, and social issues associated with stem cell research and applications; and supporting integrity in communication and publication of stem cell research and medicine. The ISSCR’s “International Guidelines for the Conduct of Human Embryonic Stem Cell Research” and “Guidelines for the Clinical Translation of Stem Cells” have been highly influential in setting standards for the field. We are currently engaged in revising and updating these guidelines to reflect ongoing technological changes and ethical concerns. Equally vital, the ISSCR works to amantadine hcl build awareness of issues that may undermine the stem cell research enterprise and is prepared to speak out in defense of rigorous standards for stem cell research and clinical trials around the world. These efforts help drive international collaboration and accelerate responsible scientific and medical discovery. The editorial standards of Stem Cell Reports exemplify the high scientific rigor that we believe needs to be applied across the continuum of stem cell research from basic investigation through clinical implementation. The ISSCR launched Stem Cell Reports with a commitment to strong editorial leadership and decision making by scientists active in the field and to deliver significant, well-documented findings to the research community. I would like to take this opportunity to thank our Editor in Chief Christine Mummery and Associate Editors Nissim Benvenisty, Thomas Graf, Hideyuki Okano, and David Scadden, who together with the editorial board have been outstanding in their dedication to this mission. We also appreciate the support of you, our advisors, reviewers, authors, and readers, who have embraced Stem Cell Reports wholeheartedly. The future for stem cell research is bright. The ISSCR and Stem Cell Reports together will work to illuminate the path ahead.
    Introduction The limited number of osteoblasts that can be obtained from animals hinders the performance of extensive studies on protein interactions, transcriptional networks, and epigenetics in osteoblast development. Therefore, pluripotent stem cell-based osteogenic differentiation may be an attractive model for such studies, given the pluripotency and capacity for self-renewal of stem cells. Although several strategies have been used to differentiate pluripotent stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into osteoblasts (Bilousova et al., 2011; Buttery et al., 2001; Li et al., 2010; Kao et al., 2010; Kawaguchi et al., 2005; Phillips et al., 2001; Tai et al., 2004; Ye et al., 2011; zur Nieden et al., 2003), none of these is a stepwise differentiation strategy that uses small molecule inducers and serum-free monolayer cultures without the formation of embryoid bodies (EBs).