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In the current study we provide evidence that
2023-10-07
In the current study, we provide evidence that enhanced ATX activity correlates well with increased ATX protein concentration during cholestasis and pregnancy (Fig. 1). Hereby we have ruled out the possibility of ATX enzyme activation in these conditions, e.g. by circulating cholephiles. ATX clearan
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In PMCA Mg favors the conversion E
2023-10-07
In PMCA, Mg2+ favors the conversion E1P → E2P [13] and, as in SERCA [11], it accelerates the phosphorylation displacing the E1–E2 equilibrium towards E1. In SERCA, Sørensen et al. [41], proposed that ATP reacts by an associative mechanism mediated by two Mg2+ ions to form an aspartyl-phosphorylated
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Significant reductions in GYN cancer patient
2023-10-07
Significant reductions in GYN cancer patient mortality and morbidity rates require treatments that proactively prevent and reverse resistance to chemotherapy and radiation. Combining chemotherapy and radiation with inhibitors of key DDR proteins targets is likely to enhance the ability of genotoxic
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Calcium Gluceptate synthesis Using the same techniques we fo
2023-10-07
Using the same techniques, we found that UCP3 also has a half-life of between 1 and 4h [117]. In Calcium Gluceptate synthesis to UCP2 and UCP3, UCP1 and ANT had much longer half-lives and could not be degraded in the cell-free reconstituted system, suggesting their degradation is not mediated by the
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br Conclusions and perspectives In view
2023-10-07
Conclusions and perspectives In view of the evidences supporting that Amoxicillin MAS receptors mediate the effects of AT1 antagonists (Iwai et al., 2012, Ohshima et al., 2014, Pernomian et al., 2015, Schuchard et al., 2015), the prime targets from the perspectives on future directions in the in
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br Experimental procedures br Results br Discussion
2023-10-07
Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this Thiola work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would like to thank D
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Overexpression of AR can lead to sorbitol
2023-10-03
Overexpression of AR can lead to sorbitol accumulation, leading to diabetic complications (Ransohoff and Cardona, 2010). Therefore, AR is an important enzyme in the growth and development of organisms. With the aim of inhibiting the activity of AR in diabetic patients, screening for inhibitors and i
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Growing evidence indicates that GRKs can exert
2023-10-03
Growing evidence indicates that GRKs can exert different effects within the cell depending on the stimulus, cell type, and localization [97], [121]. In this sense, we were the first to demonstrate a mitochondrial localization for GRK2 [122], later confirmed by other investigators [123], establishing
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Actin is capable of polymerizing
2023-10-03
Actin is capable of polymerizing spontaneously. However, this process is relatively slow and kinetically unfavorable in cells. Formation of prostaglandin receptor dimers and trimers, which can easily disassemble due to their instability, is a rate-determining step in actin polymerization [5], [6].
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Our previous studies found that some steroid mimetic structu
2023-10-03
Our previous studies found that some steroid mimetic structures such as stilbene, biphenyl, naphthalene and benzothiophene rings were suitable for lipophilic moieties of 17,20-lyase inhibitors, and several inhibitors obtained using a steroid A, C-ring mimetic approach have already been published. Du
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Another contributor for the G
2023-10-03
Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks Methylprednisolone G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al.,
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br Introduction Heart Failure HF is
2023-10-01
Introduction Heart Failure (HF) is a major and growing health challenge in India and the developing countries. It is one of the most important causes of morbidity and mortality in the industrialized world. The incidence and prevalence estimates of HF are unreliable in India because of the lack of
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In summary we suggest that both cofilin
2023-10-01
In summary, we suggest that both cofilin and gelsolin are essential factors that regulate sperm capacitation and the acrosomal exocytosis by modulating actin. The relationships between activation/inactivation of cofilin and gelsolin suggest that inhibition of cofilin is important for allowing F-acti
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resveratrol As a continuation of our search for a selective
2023-10-01
As a continuation of our search for a selective AChE radioligand bearing a meta-F substituted N-benzyl moiety, we designed and synthesized a novel meta-F-CP-118,954 analog along with a meta-18F-labeled form via diaryliodonium salt-based precursor (Fig. 1). For comparative purposes, we incorporate th
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br Material and methods br Results br Discussion The present
2023-09-28
Material and methods Results Discussion The present study demonstrates for the first time that Mino selectively induces apoptosis in Jurkat beta lactamase inhibitor via an H2O2 signaling-dependent mechanism. Structurally, Mino is composed of a C10 and C12 phenol group, C12a hydroxyl group,
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