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As with many biological phenomena immunomodulation is a doub
2018-11-14
As with many biological phenomena, immunomodulation is a double-edged sword, and many of these tolerogenic mechanisms appear to be manipulated by cancer xanthine oxidase inhibitor to create an immunoprivileged niche to further their own growth (Rabinovich et al., 2007). One of the most prominent im
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To achieve a therapeutic effect with genetically
2018-11-14
To achieve a therapeutic effect with genetically corrected iPSCs for an autologous ex vivo gene therapy approach, we must still overcome several hurdles, such as the successful transplantation of iPSC-derived myogenic cells. Since MYOD1-induced muscle ghrelin receptor from iPSCs have the ability to
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Our results show that anterior NPCs
2018-11-14
Our results show that anterior NPCs can give rise to GnRH-expressing adenosine receptor antagonist when cultured with FGF8, which has been shown to promote progenitor cell survival in the anterior neural structures (Forni et al., 2013; Kawauchi et al., 2005). In mouse anterior neural ridge, FGF8 ha
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In this study petrographic characteristics Fig a d
2018-11-14
In this Tivantinib study, petrographic characteristics (Fig. 2a–d) suggest that the tourmalines from the Hudongliang and Cuonadong Neogene magmatic rocks directly crystallized from felsic magmas, and their δ11B values should be similar to those of the magmas. The tourmalines of the Hudongliang Plio
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EZ Cap Reagent AG Additional applications for organ on
2018-11-14
Additional applications for organ-on-a-chip devices are expansive, including the assessment of environmental toxin (National Academies, 2014), modeling of disease progression and treatment (Bhatia and Ingber, 2014; Huh et al., 2012), the advancement of personalized medicine through the improvement o
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colorimetric assay Some of the identified signals can be att
2018-11-14
Some of the identified signals can be attributed to confounding by indication. This is most notable for the observed associations with lung cancers. As an example, drugs used to treat obstructive lung diseases exhibited a strong association with squamous cell carcinoma of the lung (OR, 2.61), which
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Atherosclerosis the main pathological entity that leads to c
2018-11-14
Atherosclerosis, the main pathological entity that leads to cardiovascular events, is a chronic inflammatory disease in which the innate and adaptive immune systems can play pathological or protective roles, depending on context (Hansson and Libby, 2006). Although total serum immunoglobulins (Igs) a
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Bosch et al performed frequent sampling of the nasopharyngea
2018-11-14
Bosch et al. performed frequent sampling of the nasopharyngeal microbiome during the first 6months of life, a period not well-covered by previous studies (). Thus, this study captured for the first time the most dynamic changes that occur within the first two months of life, and also showed that the
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br Funding Sources br Role of
2018-11-14
Funding Sources Role of Funding Source Conflicts of Interests Author contributions Introduction The effect of disease modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) on disease activity is generally presented using population means (Combe et al., 2015; Gabay et al.
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The role of USP has been reported recently
2018-11-14
The role of USP11 has been reported recently in modulating a number of signaling cascades such as DNA damage response, TGF-β, NF-κB and Notch signaling pathways (Ramakrishna et al., 2011; Schoenfeld et al., 2004; Wu et al., 2014; Sun et al., 2010; Al-Salihi et al., 2012). Several substrates have bee
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While we wait for such changes there is much to
2018-11-14
While we wait for such changes, there is much to be done to advance this nascent field. Firstly, there is a clear need to now refine, replicate and scale-up dietary interventions aimed at both preventing and treating common mental disorders (Sanchez-Villegas et al., 2013; O\'Neil et al., 2013). The
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In the present study we identified novel NFAT suppressors fo
2018-11-14
In the present study, we identified novel NFAT5 suppressors for use in RA therapies. We screened >40,000 small molecules which suppress NO induction and then validated anti-NFAT5 activity of the candidate molecules using an NFAT5-specific reporter. As a result, we discovered the novel NFAT5 inhibito
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br Acknowledgment br Experimental design
2018-11-14
Acknowledgment Experimental design, materials and methods In the current work, four chalcogenide glasses with nominal atomic compositions described by SeGeIn were synthesized in from elemental Se, Ge and In (all elements were of 99.99% purity) by sealing the required quantities in quartz ampou
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br Consensus and sufficiency Analysis and comparison phases
2018-11-14
Consensus and sufficiency (Analysis and comparison phases) Previously, we reported [2] that the number of minutiae annotated by examiners is strongly associated with their own value and comparison determinations, and that seven minutiae was an approximate “tipping point”: “for any minutia count g
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Data Data on sugarbeet root
2018-11-14
Data Data on sugarbeet root unigenes that were differentially expressed due to a postharvest jasmonic acid (JA) treatment are presented. Data identify unigenes that were differentially expressed 2 and 60 d after JA treatment. Data include the logarithm of the fold change in expression due to JA tre