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br Introduction Initial studies of cancer metabolism
2022-02-08
Introduction Initial studies of cancer metabolism in the early 1920s showed that the cancer phenotype for glucose metabolism is unique, with increased abilities to take up glucose and produce lactate, even under aerobic conditions [1]. This pathway, called aerobic glycolysis or the Warburg effect
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It appears that different agonists for GPR activate differen
2022-02-08
It appears that different agonists for GPR55 activate different signalling pathways [25]. GPR55 activation through LPI has been shown to trigger ERK 1/2 phosphorylation 22, 23, 25, 33. Conversely, endogenous cannabinoid compounds AEA and 2-AG have been shown to have no effect on ERK 1/2 signalling 2
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Human GPR hGPR was originally isolated in as an
2022-02-08
Human GPR55 (hGPR55) was originally isolated in 1999 as an orphan GPCR with high levels of expression in human striatum (Sawzdargo et al., 1999) (Genbank accession # NM_005683.3). hGPR55 was mapped to human chromosome 2q37, and in the human CNS it is predominantly localized to the caudate, putamen,
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Continuing studies of endocannabinoid ligands
2022-02-08
Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort
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The expression of heat shock proteins HSPs can be
2022-02-07
The expression of heat-shock proteins (HSPs) can be upregulated by viral infection, nutritional deficiency, TNF-α and oxidative stress in dilutions calculator [44], [45] HSPs are classified in six families (including the HSP10, HSP40, HSP60, HSP70, HSP90 and HSP100 families). HSP90 [46] for example
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In accordance with its similarity to
2022-02-07
In accordance with its similarity to classical NLSs, Importin α3 was recently reported as a nuclear transport receptor for Ci (). We therefore superimposed the Gli1 NLS model with the Importin α2 structure (3EFX), which has a structure similar to Drosophila Importin α3 () (Fig. 4.4B). Gli1 NLS fitte
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Next we asked how a common activation marker of
2022-02-07
Next, we asked how a common activation marker of fibroblasts, Acta2, defined gene expression signatures in alveolar airspaces by using Acta2-mKO1 reporter mice (Fig. 2A). In the lungs of Acta2-mKO1 mice, mKO1 was expressed in smooth muscle cells and mesenchymal cells in herpes simplex virus 1 (Fig.
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Immunohistochemistry analysis shown ghrelin and GHSR
2022-02-07
Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of MRT67307 HCl and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many tissues, including
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The role of cell to cell interactions in coordinating the
2022-02-07
The role of cell-to-cell interactions in coordinating the cells’ behaviour to ensure an appropriate anterior pituitary hormone response is receiving increasing attention. Anterior pituitary 2403 australia interact with neighbouring cells through junctional complexes. As their name implies, the comp
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The focused set of additional pyrazole analogs allowed the i
2022-02-07
The focused set of additional pyrazole analogs allowed the identification of three additional moderately potent γ-secretase modulators, , and which were subsequently screened in a kinetic solubility assay. Unfortunately, neither the architectural changes in analog nor the integration of trifluoro
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Neovascularization upon IMQ treatment was observed to
2022-02-07
Neovascularization upon IMQ treatment was observed to different degrees in WT and GAL3-KO mice, whereas the increase in vascular endothelial growth factor mRNA levels was genotype independent. Because we observed lower levels of the cytokines IL-17A, IL-22, IL-23, and TNF-α in IMQ-treated skin of GA
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FPR family Human FPR was first defined
2022-02-07
FPR family Human FPR was first defined biochemically, in 1976, as a high affinity binding site on the surface of neutrophils for the prototypic N-formyl peptide formyl-methionine-leucyl-phenylalanine (fMLF). It was then cloned in 1990, by Boulay et al. from a differentiated HL-60 myeloid leukemia-c
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br Role of funding source br Conflict of
2022-02-05
Role of funding source Conflict of interest Acknowledgements We thank F. Blaskovits and P. Kesner for technical assistance. This project was supported by operating grants from the Canadian Institutes of Health Research (CIHR) to X. Zhang (MOP123249) and the National Natural Science Foundati
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br Introduction Stroke is the second cause of death
2022-02-05
Introduction Stroke is the second cause of death worldwide and the first cause of acquired motor disability in adults [1], [2]. In sub-Saharan Africa, stroke is the first cause of admission in neurology departments [3]. In Cameroon, the in-hospital mortality of stroke is estimated at 26.8% [4]. A
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Lieber have discussed alcohol outside the context
2022-02-05
Lieber (2000), have discussed alcohol outside the context of hepatitis C infection exerts specific pathologic effects on the liver. Liver biopsies in patients with hepatitis C who drink alcohol are generally consistent with hepatitis C alone, with portal-based pathology, rather than alcoholic injury
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