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The Scribble complex localizes to the leading edge
2022-01-12
The Scribble complex localizes to the leading edge in response to integrin engagement. There, Scribble controls the activation Rac and PAK via the Rac GEF β-Pix (Bahri et al., 2010), which is required for collective cell migration (Omelchenko et al., 2014). However, on the rear edge, Scribble can be
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Introduction Epigenetic alterations play an important
2022-01-12
Introduction Epigenetic alterations play an important role in carcinogenesis. Aberrant promoter CpG island hypermethylation causes transcriptional gene silencing [1], and has been documented for a number of genes in prostate cancer (PCA) [2]. Histone modifications are also important regulators of t
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GPR belongs to the G protein coupled
2022-01-12
GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty ampa receptor (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone mar
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While a role for YAP TAZ signaling in oligodendrocytes has
2022-01-12
While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these CCK-8 receptor are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manne
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Notably we observed that GPR activation induced
2022-01-12
Notably, we observed that GPR35 activation induced by PA, an in vivo GPR35 agonist [6], significantly decreased DAI, colon weight, and histological score, while increasing colon length in mice with DSS-induced colitis. Furthermore, fibronectin and integrin α5 were co-localized with GPR35 on the col
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gssg mg In addition to these effects on metabolic function i
2022-01-12
In addition to these effects on metabolic function in cardiac cells, this study also demonstrates changes in the expression of hypertrophic genes and proteins subsequent to GPR119 activation. Again this occurred in a distinct pattern dependent on palmitate exposure. Of interest SOCS3 mRNAs were decr
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Sodium Orthovanadate receptor Fig summarizes the underlying
2022-01-12
Fig. 7 summarizes the underlying mechanism of SB on inhibiting inflammation and maintaining epithelium barrier integrity in the TNBS-induced colitis model. Our findings not only explained the protective effect of SB on colon health, but also provided evidence that GPR109A likely constitutes a valid
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The combination of niacin with a selective PGD receptor anta
2022-01-12
The combination of niacin with a selective PGD2 receptor antagonist laropiprant, designed to circumvent the flushing side effect of niacin, has been evaluated in the HPS2-THRIVE study and showed no clinically meaningful benefit when administered in patients on top of statin therapy [41]. Our data su
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caspofungin In this study we investigated the contribution
2022-01-11
In this study, we investigated the contribution of GCK, G6PC, and PCK expression to glycemia in diabetes. We examined liver tissue from 40 obese subjects: 12 had normal glucose tolerance (NGT) and 28 had type 2 diabetes. Materials and methods Results Discussion This study aimed to investig
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The in vivo biological activity
2022-01-11
The in vivo biological activity of the four novel analogues was then systematically assessed in three animal models including normal control, high fat fed and ob/ob mice. As expected from earlier in vitro studies, all four glucagon receptor antagonists had minor effects on glucose or insulin concent
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Since the Gardos channel Ca
2022-01-11
Since the Gardos channel Ca2+ sensor have been shown to be constitutively bound calmodulin [16] and the PMCA is activated by association to a calcium–calmodulin complex, it seems probable that the NS309 agonist effect is caused by direct interaction with the Gardos channel, and not by an action on c
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Optimization of the tetrahydroindazole series
2022-01-11
Optimization of the tetrahydroindazole series led to the discovery of two moderately potent γ-secretase modulators, 2-cyclobutane and 2-hydroxy-2-methylpropane which were subsequently evaluated in a kinetic aqueous solubility assay. Unfortunately, neither analog demonstrated improved solubility ()
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fasudil sale Some previous findings indicate that GALP has a
2022-01-11
Some previous findings indicate that GALP has an influence on AVP and OT secretion from the posterior pituitary gland. Cunningham et al. (2004) noted that the expression of GALP mRNA was increased in the neurohypophysis of lactating rats compared to non-lactating rats, whereas GALP mRNA expression i
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br Materials and methods br Results br Discussion In
2022-01-11
Materials and methods Results Discussion In this study, we identified a novel AMP scolopendrasin X from Scolopendra subspinipes mutilans through genome analysis. Scolopendrasin X stimulated neutrophil activity, resulting in calcium increase, chemotactic migration, and superoxide anion produ
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br Characterization of quantal exocytosis
2022-01-11
Characterization of quantal exocytosis by amperometry A secretory vesicle experiences four phases during exocytosis: (i) cargo packaging & translocation, (ii) vesicle docking & priming; (iii) fusion pore formation; (iv) fusion pore expansion and cargo secretion (Fig. 1a). The release of monoamine
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