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PBI is an agonist of GPR and acts as
2021-12-15
PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th
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Research of Kojima et al DeJarnette et al
2021-12-15
Research of Kojima et al. (2000); DeJarnette et al. (2001), and Saldarriaga et al. (2007) inferred that synchronization of NFWE is related to ovulation response after GnRH-1. In the research of Saldarriaga et al. (2007) with Bos indicus-influenced beef cows, ovulation rate was 40% and estrous synchr
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br Regulation of gonadotropins by GnRH GnRH
2021-12-15
Regulation of gonadotropins by GnRH GnRH is released from the hypothalamus, and its release pattern is known to be pulsatile. That is, the pulse frequency and amplitude of GnRH release vary physiologically during reproductive cycles in females, and differentially stimulate the production and rele
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br Conflict of interest br Funding br Acknowledgements br In
2021-12-15
Conflict of interest Funding Acknowledgements Introduction to SLC6 transporters The solute carrier (SLC) 6 family of membrane proteins perform the Na+-coupled symport of amino acids and amino SCH772984 derivatives into cells throughout the body. Disrupting neurotransmitter SLC6-mediated
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Focal adhesion kinase FAK also known as
2021-12-14
Focal adhesion kinase (FAK), also known as protein tyrosine kinase2 (PTK2), is a tyrosine kinase and vital member in integrin-mediated signaling pathways [3]. In response to integrin involvement, FAK would be phosphorylated. It was reported that FAK is involved in cellular adhesion and spreading [4]
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During the activation of the coagulation cascade factor Xa
2021-12-14
During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium ptc chemical on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directly inhibit p
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Relative to the impact of moderate PAE on markers
2021-12-14
Relative to the impact of moderate PAE on markers of histaminergic neurotransmission, there were four salient observations from the studies reported here. First, it does not appear that moderate PAE affects the number of HDC-positive neurons in the tuberomammillary nucleus of the ventral hypothalamu
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br Background To treat chronic HCV
2021-12-14
Background To treat chronic HCV genotype (GT) 1-infected patients, telaprevir (TLP) or boceprevir (BOC), first generation protease inhibitors (PIs), were used in combination with pegylated-interferon (PEG-IFN) and ribavirin (RBV) triple therapy [1], [2]. The main weaknesses of the first-generatio
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Among RASs observed in patients
2021-12-14
Among RASs observed in patients from group 2, RAS T54S was identified in one patient infected with subtype 1b. This mutation had been shown to cause resistance to boceprevir and telaprevir, but not to simeprevir [36]. This was confirmed here since this patient achieved SVR after 12 weeks of treatmen
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br Experimental br Acknowledgements This work was
2021-12-14
Experimental Acknowledgements This work was financially supported by Ministry of Knowledge and Economy (10032113) and Ministry of Education, Science and Technology (20100000297). Introduction To ensure accurate chromosome segregation, cohesion between sister chromatids must be maintained u
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The physiological role of lactate induced antilipolytic effe
2021-12-14
The physiological role of lactate-induced antilipolytic effects is less clear. It has been speculated that GPR81 mediates the inhibition of lipolysis during intensive exercise, a condition which results in high systemic lactate plasma concentrations 9, 10. Owing to oxygen shortage resulting from int
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LPCs have been previously described as
2021-12-14
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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br Conclusion br Author contributions br
2021-12-14
Conclusion Author contributions Competing interests Acknowledgments Introduction Reproductive performance is a major factor affecting profitability of dairy farms. The use of GnRH and prostaglandin F2α (PGF2α) in a coordinated fashion allows cows to be inseminated as a result of the u
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The current study also inferred that
2021-12-14
The current study also inferred that MT content in Crassostrea gigas might be associated with the Cd level, and can be affected by MT turnover. The GSK2606414 of MT in cytosol is beneficial for aquatic organisms to adapt the seawater contaminated by heavy metals, and MT is a biomarker for marine in
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It is well known that GPCR responsiveness desensitizes
2021-12-14
It is well known that GPCR responsiveness desensitizes after prolonged exposure to agonists through several mechanisms such as receptor phosphorylation, arrestin binding and internalization (Dhami and Ferguson, 2006). Therefore, in the present work we decided to study whether group I-mGluR signaling
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