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br Acknowledgments br Introduction Cell
2020-09-22
Acknowledgments Introduction Cell cycle arrest or delay may occur at 3 major checkpoints, i.e. G1/S, intra-S and G2/M. p53 has a central role in controlling the G1/S checkpoint, and its loss or deactivation, occurring in the majority of cancers, forces cancer cells to rely on the S and G2/M ch
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The work described by Dong Groves and co workers tested
2020-09-22
The work described by Dong, Groves, and co-workers (11) tested the hypothesis that neural stem cell development is sensitive to the clustering and mechanical state of the EphB4:ephrin-B2 receptor-ligand complex. They show that the quality of ephrin-B2-ligand signaling depends on its biophysical stat
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The applications of fungal enzymes in
2020-09-21
The applications of fungal enzymes in paper industry involve biobleaching of pulp, pulp de-inking, degradation of dissolved and suspended organic compounds in concentrated effluents of mills and enhanced fibrillation. Enzymes usage is encouraged in paper industry in order to reduce the use of chemic
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Importantly we observed significantly the
2020-09-21
Importantly, we observed significantly the reduced myocardial infarct size, the improved left ventricular function and the inhibited fibrosis after I/R with oral GA-BH4 supplementation before ischemia (Fig. 1, Fig. 2, Fig. 3). Usually, there is a view that the antioxidation induced by reducing agent
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PI K is a lipid kinase and
2020-09-21
PI3K is a lipid kinase and generates phosphatidylinositol-(3,4,5)-trisphosphate, which is a second messenger critical for the translocation of Akt to the cytoplasmic membrane. The phosphorylation of Ser473 Akt is important in the cell survival by regulating the eNOS among other targets (Dimmeler et
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br Introduction Epithelial mesenchymal transition EMT
2020-09-21
Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial autotaxin inhibitor lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation during
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In contrast to SQLE HMGCR could be efficiently degraded in
2020-09-21
In contrast to SQLE, HMGCR could be efficiently degraded in 99021 lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recently repo
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Mono and bi ubiquitination of two
2020-09-21
Mono- and bi-ubiquitination of two lysines, namely K70 and K76, in a small fraction of p33 replication co-factor has been demonstrated in yeast (Barajas and Nagy, 2010, Li et al., 2008). Because mutations of these lysines reduced TBSV repRNA replication in yeast and affected the ability of p33 to in
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br Acknowledgments The authors thank Dr
2020-09-21
Acknowledgments The authors thank Dr. Tai-Sheng Cheng, Yu-Wen Huang and Ting-Wei Gau for technical assistance. This work was supported by the National Science Council of TaiwanNSC 98-2320-B-024-002-MY3 and National University of TainanAB102-216. This information is available free of charge via th
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br Deubiquitination deubiquitinases and cancer Protein deubi
2020-09-21
Deubiquitination, deubiquitinases and cancer Protein deubiquitination is reverse process of ubiquitination and performed by deubiquitinases or deubiquitinating enzymes (DUBs), which help in removal of ubiquitin from target proteins and involve in ubiquitin maturation, recycling and editing (Pfoh
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Introduction BRs are well known class of steroid phytohormon
2020-09-21
Introduction BRs are well known class of steroid phytohormones involved in the regulation of key processes of plant growth and development [1], [2], [3], [4], [5]. A lot of attention is driven to BRs in the last decade because of their undeniable functions in promoting NECA reactions of plants to
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In the present study we
2020-09-21
In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis Ponesimod and leaves, we demonstrate that this sub-class of plant proteases is activated in re
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The small GTPase Ran regulates karyopherin cargo
2020-09-19
The small GTPase Ran regulates karyopherin–cargo interactions and the directionality of karyopherin-mediated transport. Like other Ras-family GTPases, Ran cycles between GTP- and GDP-bound states, and the two surface loops in Ran, referred to as the switch I and switch II loops, undergo significant
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5 alpha reductase inhibitor We and others have previously fo
2020-09-19
We and others have previously found that supplementation of old rats with ALCAR remediates the age-related decay in mitochondrial bioenergetics in liver (Hagen et al., 1998a, Hagen et al., 1998b), heart (Paradies et al., 1994, Paradies et al., 1999), muscle (Pesce et al., 2010) and 5 alpha reductase
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Nicotine It is well known that the tumor suppressor
2020-09-19
It is well known that the tumor suppressor p53 plays an important role in regulating the Nicotine and cellular senescence [43,46,48]. For example, FOXO4 could interact with P53, which selectively induced apoptosis in senescent cells [48]. In addition, loss of MECP2 was found to lead to the induction
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