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MAPKs are a family of phosphorylating enzymes
2020-07-14
MAPKs are a family of phosphorylating enzymes that orchestrate various cellular response in proliferation, apoptosis, inflammation, stress response, and energy metabolism [11]. There are at least four major members including extracellular signal-regulated kinase 1 and 2 (ERK1/2), p38 mitogen-activat
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Increased leukocyte trafficking and infiltration of the vasc
2020-07-14
Increased leukocyte trafficking and infiltration of the vascular wall are thought to provide a key stimulus for SMC activation and subsequent neointima formation in response to vascular injury [19], [20]. The essential trigger regulating the accumulation of leukocytes in the vessel wall is the upreg
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Nitric oxide synthase NOS is a predominant enzyme
2020-07-14
Nitric oxide synthase (NOS) is a predominant enzyme of immune system, which elaborates nitric oxide (NO) from the amino Ruxolitinib phosphate arginine (Arg). NO mediates vasodilatation, blood pressure regulation, neurotransmission, host defense, and macrophage-mediated immunity, among an array of ot
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Herein we explored by docking studies the
2020-07-13
Herein, we explored by docking studies the effectiveness of replacing the dimethyl substitution at C (6) of dihydrotriazine with a folded azaspiro-containing substituent, along with the introduction of differently substituted phenyl- and benzyl-rings or alkyl chains, linked at the position 1 of the
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br Materials and methods br Results br Discussion This study
2020-07-13
Materials and methods Results Discussion This study is the first to our knowledge that describes upstream cis-elements and transcription factors that are important for Crm1 expression and that drive its high expression in cancer and transformed cells. Using deletion and mutation analysis we
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Enolases are among the most
2020-07-13
Enolases are among the most abundantly expressed cytosolic proteins. They are metalloenzymes that catalyze the conversion of 2-phosphoglycerate to phosphoenolpyruvate [18]. Eubacteria and archaebacteria have a single enolase gene (reviewed in [19]). Despite the lack of signal peptides or cognate pro
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AXL1717 sale In contrast to SQLE HMGCR could be efficiently
2020-07-13
In contrast to SQLE, HMGCR could be efficiently degraded in AXL1717 sale lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recen
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br Introduction Type Diabetes mellitus T DM is a metabolic
2020-07-13
Introduction Type 2 Diabetes mellitus (T2DM) is a metabolic disorder that raises blood glucose level for a prolonged time. T2DM is associated with acute complications like ketoacidosis, hyposmolar coma, chronic complications include heart disease, stroke, kidney failure, foot ulcers and damage to
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Mother rats acutely treated with quinpirole and mg kg
2020-07-13
Mother rats acutely treated with quinpirole (0.5 and 1.0 mg/kg) decreased the pup exploration time but increased the object exploration, so they showed a significantly lower pup preference ratio. They also showed impaired maternal performance in the home cage, consistent with our previous study (Zha
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cGAS has a central role in STING
2020-07-13
cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested
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br Materials and Methods br Acknowledgements br Introduction
2020-07-13
Materials and Methods Acknowledgements Introduction Collagen fibrillogenesis, the assembly of collagen fibers, is a critical process in the development, maturation, and repair of mammalian tissue. Alterations in the structure and amount of deposited collagen fibers can greatly alter the int
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br Results and Discussion br Conclusions
2020-07-13
Results and Discussion Conclusions Based on their common NTP pyrophosphatase activity, similar size of the catalytic domains, and the conservation of glutamate residues, it was assumed previously that the MazG and HisE families were related to MutT and other Nudix family hydrolases (see Zhang
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In present study we measured the
2020-07-13
In present study, we measured the methylation and Quetiapine sale levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is a h
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Ligand independent constitutively active variants have also
2020-07-11
Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases. In approximately 60% of patients harboring inflammatory hepatocellular adenomas (IHCAs), these adenomas have been caused by small in-frame deletions in the cytokine-binding domain o
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In the present study we used a new luminescent
2020-07-11
In the present study, we used a new luminescent method to measure CYP activity with Luciferin-ME as a substrate which is used for wide ranges of mammalian CYPs, including CYP1A2, CYP2C8, CYP2C9, CYP2J2, CYP4A11, and CYP4F3B. As a result, no significant modulations of CYP activities in B[a]P exposure
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