• The concept of hematopoietic stem cells More than a

  2018-11-08

  

  The concept of hematopoietic stem cells: More than a century ago The development of cell biology research coincides with the advance of microscopes in the 19th century. It was finally possible to directly observe the various blood cell types and to witness their proliferation and differentiation (M

• Our findings indicate that rat

  2018-11-08

  

  Our findings indicate that rat ESCs are more sensitive to GSK inhibition primarily because of the relative abundance of LEF1, which favors the activation of differentiation genes. Their collective expression may challenge and destabilize the self-renewal circuitry. The TOPFlash assays also suggest t

• The authors would like to thank Felecia Codrea and Jessica

  2018-11-08

  

  The authors would like to thank Felecia Codrea and Jessica Scholes of the UCLA BSCRC FACS core, Suhua Feng of the UCLA BSCRC Sequencing core, and Tiasha Shafiq for immunostaining. This project was funded by NIH grant P01HD075795. Time-mated breeding was supported by NIH OD P51OD011092 (J.D.H.). The

• RG cells have been generated from a

  2018-11-08

  

  RG cells have been generated from a variety of different sources of embryonic and adult brains, and embryonic stem cells (Conti et al., 2005; Liour and Yu, 2003; Bibel et al., 2004; Malatesta et al., 2000). In addition to isolating RG cells from human fetal tissue (Mo et al., 2007), it has recently

• To date safety studies in humans do not have

  2018-11-08

  

  To date, safety studies in humans do not have extended follow-up in particular with respect to the evaluation of MSC tumorigenic potential. Investigations described in this review were certainly validated by institutional ethics committees; however, not only registered- and university affiliated-inv

• br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by 17 alpha hydroxylase that were not multipotent, based upon their differentiation capacity

• We chose to use the human GFAABC D promoter to

  2018-11-08

  

  We chose to use the human GFAABC1D promoter to drive TagRFP in human astrocytes because of its accuracy to specifically direct reporter expression in astrocytes in several CNS regions, at embryonic and adult stage, in rodent (Lee et al., 2008). Interestingly, during the pre-screening stage, at 70 DI

• In our prior studies we showed that K

  2018-11-08

  

  In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer Digoxigenin-11-ddUTP through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG12D promote

• somatostatin receptor The identification of stem cells or pr

  2018-11-08

  

  The identification of stem somatostatin receptor or progenitor cells, and their contribution to pancreatic regeneration remain controversial (Ziv et al., 2013; Burke and Tosh, 2012). The pancreas uses several regenerative mechanisms. Self-renewal is the principal mechanism of acinar and islet regen

• After comparing the lymph angiogenic effects of HLE and HLF

  2018-11-08

  

  After comparing the (lymph)angiogenic effects of HLE and HLF, UVB-induced changes in their protein expression patterns were also assessed. As shown by the protein array assessment, following UVB irradiation of HLF national prevalence  amphiregulin, uPA (a strong promoter of angiogenesis (Oh et al.,

• Similar to our in vitro results

  2018-11-08

  

  Similar to our in vitro results, transplanted iNSCs exhibited in vivo-characteristics, transcriptome profiles, neural and metabolic programs similar to those of transplanted NSCs. In contrast to engrafted forebrain NSCs, however, transplanted iNSCs strongly expressed caudal regional marker genes and

• To confirm the pluripotency of the MIXL eGFP

  2018-11-08

  

  To confirm the pluripotency of the MIXL1-eGFP hESCs, the expression of several pluripotency markers was analyzed by quantitative real-time PCR as well as immunocytochemsitry. Endogenous expression of NANOG, OCT4 and SOX2 was determined at the mRNA level by real-time PCR (Fig. 1C). Protein expression

• Unfortunately exploration of the biochemical

  2018-11-08

  

  Unfortunately, exploration of the biochemical mechanisms that underlie germ cell specification and early PGC formation in the mammalian embryo is hampered by the scarcity of neutrophil elastase inhibitor at these early embryonic time points. In vitro derivation of PGCs from embryonic stem cells (ES

• Following fundamental analysis of pharmacological

  2018-11-08

  

  Following fundamental analysis of pharmacological and electrophysiological features of suspension-derived CMs, we have demonstrated direct applicability of bioreactor-produced EBs for tissue engineering. While BCT generation from undissociated, contracting spheres was recently shown, this required g

• Partial cleavage of CXCL at the N

  2018-11-08

  

  Partial cleavage of CXCL12 at the N-terminus by distinct peptidases results in loss of chemotactic activity and impairment in CXCR4 receptor affinity (Cho et al., 2010; Delgado et al., 2001; Levesque et al., 2003). The proteolytic cleavage of CXCL12 by matrix metalloproteinase 2 and 9 (MMP-2 and 9)

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