• It is well known that acrolein

  2019-07-02

  

  It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o

• Repulsive interactions towards undesirable substrates

  2019-07-02

  

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and explo

• CCR is another chemokine receptor

  2019-07-02

  

  CCR7 is another chemokine receptor that is upregulated in CLL [3], [61], [71], [96] and is believed to play a role in enabling cell entry into lymph nodes [97]. Higher mRNA and protein expression of CCR7 has been observed in unmutated compared to mutated IGHV CLL [46] and increased expression has be

• Eggs have been recognized as an important contributor

  2019-07-02

  

  Eggs have been recognized as an important contributor of functional ingredients for humans [3]. Egg yolk is composed of various biologically active proteins. The water-soluble proteins of egg yolk have been examined for their functional effects on longitudinal bone growth during the growth period in

• Palliative surgeries for refractory epilepsy include

  2019-07-01

  

  Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor

• Intrahepatic cholangiocarcinoma ICC originates from the smal

  2019-07-01

  

  Intrahepatic cholangiocarcinoma (ICC) originates from the small intrahepatic ductules or the large intrahepatic ducts proximal to the bifurcation of the right and left hepatic ducts. ICC is the second most common primary malignancy of the liver after hepatocellular carcinoma (HCC). Given the rising

• Lead failures are classified as either structural lead failu

  2019-07-01

  

  Lead failures are classified as either structural lead failures or electrical lead failures, and failures of 8F single coil leads are more frequently reported. Structural failures occur with a reported incidence of 14–34% and are evident as cable exteriorization in fluoroscopy studies [6,7]. Electri

• More than million almost children younger than years in

  2019-07-01

  

  More than 200 million—almost 40%—children younger than 5 years in developing countries are not fulfilling their developmental potential. In parts of Africa, up to three-quarters of children are victims of physical abuse, and a third of girls and more than 10% of boys are victims of sexual abuse. One

• Both breast cancer and MM

  2019-07-01

  

  Both breast cancer and MM cause osteolytic lesions, inhibiting osteoblast differentiation and thereby tipping the balance in favour of osteoclastic activity. In contrast, prostate cancer predominantly causes osteoblastic bone disease. Interestingly, increased marrow adiposity has been associated wit

• br Conflict of interest br Introduction Landiolol is

  2019-07-01

  

  Conflict of interest Introduction Landiolol is an intravenous short-acting beta-adrenoreceptor blocker, and its wide use is exhibited by rapid wash out and a less-sustained effect on cardiac function after decreasing the dose or stopping its administration [1]. We present a patient with drug-r

• Hasta el tercer acto cuando Licurgo se casa y

  2019-07-01

  

  Hasta el tercer acto, cuando Licurgo se casa y vuelve aa-dutp la racionalidad, presenta al Rey una serie de leyes, quien, sin conocerlas, le pregunta si desea hacerlas públicas, pero, desde otra óptica, Licurgo responde: Son, pues, el Rey y el Reino quienes deben acordar las leyes, para evitar caer

• Seg n Auerbach la parataxis es un modo

  2019-07-01

  

  Según Auerbach, la parataxis es un modo primitivo y anticlásico de narrar, típico de la Edad Media, que será sustituido gradualmente por maneras más modernas y finas de describir la realidad. No obstante, en fechas recientes ha vuelto Phos-tag of ser practicada, por ejemplo por una serie de poetas e

• br Over the past decade a growing number of

  2019-06-29

  

  Over the past decade, a growing number of studies have linked urban green space and aspects of AZD1480 with emotional wellbeing. Although the existing body of epidemiological work has been very encouraging—collectively providing a strong argument that access to areas rich in vegetation, bodies of

• br Discussion Variant angina was described by

  2019-06-29

  

  Discussion Variant KC7F2 was described by Prinzmetal et al. in 1959 [1]. It can involve serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, and atrioventricular block, and patients are particularly susceptible to sudden cardiac death in such cases [2,3]. Coronary spast

• Cost effectiveness is another major

  2019-06-29

  

  Cost effectiveness is another major concern for the governments in countries with public health system. Van-den Hout WB et al. at Netherlands [7] did a cost utility analysis showing the cost of radiation treatment including re-treatment for bone metastases using SF versus MF were €2438 versus €3311

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