trp channel Background green fluorescence was detected in th

2018-10-20

Background green fluorescence was detected in the lentiviral reprogrammed MML-6838-CL2 iPSC line and a control episomal (non-GFP) reprogrammed iPSC, indicating silencing (Fig. 1B). Pluripotency was confirmed by detecting expression of SOX2, OCT4, SSEA4, TRA1-61 and TRA1-80 pluripotency-associated ma

Previously we showed that the

2018-10-20

Previously, we showed that the transcription factor SLUG is an important regulator of mammary epithelial lineage commitment and differentiation (Proia et al., 2011). Recent studies have also shown that SLUG is necessary for the mammary stem cell state (Guo et al., 2012). However, SLUG-deficient mice

br Introduction Cell based therapies are emerging as

2018-10-20

Introduction Cell-based therapies are emerging as one of the most promising approaches of regenerative medicine (Riazi et al., 2009). In the kidney field, the search for a renal-specific stem cell led to the discovery of progenitor order SCH772984 that protect animals from acute kidney injury (A

Human mesenchymal stem cells are adult multipotent stromal c

2018-10-20

Human mesenchymal stem autotaxin inhibitor are adult multipotent stromal cells which differentiate into multiple cell types (Bianco et al., 2013; Castro-Manrreza and Montesinos, 2015). While in terms with the expeditious advances in the field of mesenchymal stem cell (MSC) research, the ambiguity o

Pax is a well known neurogenic transcription

2018-10-20

Pax6 is a well-known neurogenic transcription factor that is essential for the development of multiple neural tissues (Gehring and Ikeo, 1999; Georgala et al., 2011; Zhang et al., 2010). Due to its important role in neuronal development, Pax6 was often included in the initial screening for essential

The neurogenic to gliogenic transition of NSPCs

2018-10-20

The neurogenic-to-gliogenic transition of NSPCs is probably governed by a multi-layered system. The epigenetic status of astrocyte-specific (Takizawa et al., 2001) and neurogenic genes changes during development (Hirabayashi et al., 2009; Kishi et al., 2012; Pereira et al., 2010), critically determi

GDC-0994 Although inhibition of p MAPK signaling prevented

2018-10-20

Although inhibition of p38 MAPK signaling prevented spontaneous differentiation of huSCs ex vivo, this effect was reversible. After 2 weeks of expansion in the presence of p38i, the drug was chased for a period of 5 days, during which we observed a significant increase in MYOG expression (Figure S4A

In mouse embryos both the developing retina and

2018-10-20

In mouse embryos, both the developing retina and the ventral hypothalamus show strong Rax expression (Ikeda et al., 2005; Wataya et al., 2008; Wilson and Houart, 2004). Consistent with previous studies (Ikeda et al., 2005; Wataya et al., 2008), we confirmed that SHH agonists upregulated Rax in mESCs

The most commonly used trophoblast markers reported in the l

2018-10-20

The most commonly used “trophoblast” markers reported in the literature are cytokeratin 7 (KRT7), HLA-G, and human chorionic gonadotropin (hCG), but these are either not specific to all trophoblast O4I1 or are expressed in other cell types. Several of the transcription factors (TF) that define the

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2018-07-29