• An AmDH is engineered by mutating

  2020-02-20

  

  An AmDH is engineered by mutating two conserved amino gap junction residues in the active site of an amino acid dehydrogenase (AADH). Starting from the leucine dehydrogenase (LeuDH) from Bacillus stearothermophilus, substituting a serine and leucine at the K68 and N261 positions, respectively, resul

• The question remained as to why hCrm was functional

  2020-02-20

  

  The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human Lonidamine had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE comple

• This letter reports an ab initio study on

  2020-02-20

  

  This letter reports an ab initio study on the X peaks of PES by including the SO effect. The multiplet split energies are calculated with the SO-MCQDPT2 method [21], and the so-called pole strengths are evaluated to simulate the relative intensities. The results are compared with the experimental PE

• The GH family includes also

  2020-02-20

  

  The GH30 family includes also xylanases which are not MeGlcA-dependent. Most of them are grouped to GH30_7 subfamily that includes XynIV from Trichoderma reesei showing exo- and endo-xylanase activity [11] and XYLD from Bispora sp. MEY-1 [12] having activity towards glucuronoxylan and arabinoxylan,

• The prospects of the use

  2020-02-20

  

  The prospects of the use of this novel approach for the selective local thermo-activation of enzymes include biomedical and biotechnological applications. As NPs could be engineered to gain access to PRT062607 Hydrochloride through the endosomal compartment [47] or through non-endocytotic pathways

• Support for Cloninger s personality theory comes also

  2020-02-20

  

  Support for Cloninger\'s personality theory comes also from molecular genetic studies. Given the high heritability of personality it is plausible that gene variants explain variance in RD. In AT13148 receptor to endocrine studies, which relate hormone levels mostly in the periphery (blood, saliva, u

• It is well established that p maintains genomic integrity in

  2020-02-20

  

  It is well established that p53 maintains genomic integrity in response to a variety of cell stresses including DNA damage and oncogenic stress among others [6], [7], [8], [9]. p53 promotes the expression of several genes to cause Epibrassinolide arrest and to repair cellular damage. There is growi

• br Acknowledgements Thanks are due to Science

  2020-02-20

  

  Acknowledgements Thanks are due to Science and Technology Development Fund – Egypt for the Research Support Technology Development Grant (RSTDG) no. 12626. Our deep thanks and gratitude is also extended to National Cancer Institute (NCI), Bethesda, Maryland, USA for performing the anticancer eval

• Aspergillus nigerA niger is another

  2020-02-20

  

  Aspergillus nigerA. niger is another filamentous fungus, in which alternative dehydrogenases have been described. Filamentous fungi are a very important group of microorganisms that are used in industry (O’Donnell et al. 2011). Biotechnological production processes using these organisms are often hi

• Ligand independent constitutively active variants have also

  2020-02-20

  

  Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases. In approximately 60% of patients harboring inflammatory hepatocellular adenomas (IHCAs), these adenomas have been caused by small in-frame deletions in the cytokine-binding domain o

• br Chagas disease Chagas disease an NTD

  2020-02-20

  

  Chagas disease Chagas disease, an NTD caused by the protozoan Trypanosoma cruzi, affects 8–10 million people globally. More than 10,000 deaths are caused by the disease each year, and nearly 70 million people are susceptible to infection (Manne-Goehler, Umeh, Montgomery, & Wirtz, 2016). Chagas di

• Most remarkably an essentially identical collagen binding mo

  2020-02-20

  

  Most remarkably, an essentially identical collagen-binding mode to DDR2 is employed by SPARC, an α-helical matricellular protein unrelated to DDR2 that also recognizes the GVMGFO motif in collagen (Giudici et al., 2008, Hohenester et al., 2008). The convergence of binding mechanisms suggests that th

• Immunofluorescence Cells were fixed with paraformaldehyde PF

  2020-02-19

  

  Immunofluorescence. Cells were fixed with 4% paraformaldehyde (PFA) in PBS and extracted by 0.5% Triton X-100-PBS, or fixed in cold methanol. The cells were immunostained with mouse monoclonal Talabostat mesylate australia against α-tubulin (Sigma), γ-tubulin (Sigma), Ran (Upstate), rabbit polyclon

• In this study we observed alterations in mRNA

  2020-02-19

  

  In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased Peramivir receptor when the sensitization condition was established. Similarly, CRF2 recept

• br Acknowledgements This work was supported

  2020-02-19

  

  Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360. We are grateful to Dr. T.T. Hoang for the provision of plasmids pEX18Tc, pPS858 and pFLP2, Prof. B.L. Wanner for providing us with the plasmid pKD4 and related strains, and Prof. P. Soucail

15560 records 850/1038 page Previous Next First page 上5页 846847848849850 下5页 Last page