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Ultraviolet radiation UVR can stimulate melanin production
2019-04-16
Ultraviolet radiation (UVR) can stimulate melanin production in human epidermal melanocytes. It is reported that the MC1R-cAMP pathway plays an important role in UVR-induced tanning [22]. Similar to the UVR-induced effect, p38 MAPK signaling is involved in stress-induced melanogenesis. A previous st
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A year old male with
2019-04-16
A 52-year-old male with known dextrocardia and CCTGA presented with a 2-month history of recurrent presyncope and effort intolerance. His examination revealed a resting pulse rate of 52beats/min (bpm) and a blood pressure of 130/80mmHg. The apex beat and heart sounds were appreciated on the right si
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Upon examining his previous hospital records from years prio
2019-04-16
Upon examining his previous hospital records from 4 years prior, we found that he was diagnosed with acute heart failure at the second hospitalization 1 week after catheter ablation for atrial fibrillation. His symptoms and chest radiographic findings had improved by standard therapy for heart failu
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In summary we have established an
2019-04-16
In summary, we have established an animal model of human NB bone metastasis in which COX-2/PGE2 plays a critical role. We provide pre-clinical data supporting the use of COX-2 inhibitors in the treatment of bone metastases in NB. Conflict of interest statement Introduction Desmoplastic fibrom
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Paying now rather than forever has
2019-04-16
Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set
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De esta manera los estados
2019-04-16
De esta manera, los estados latinoamericanos se han redefinido desde aquello que puede denominarse cautela y desconfianza. Dichos estados son la materialización de la desconfianza histórica, de la amplitud del margen del conocimiento, de la apreciación de que no todo va bien y por supuesto, de una “
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br Methods br Results Among patients
2019-04-15
Methods Results Among 36 patients with 37 long RP tachycardias, there were 22 patients with 23 ATs (62%) and 14 patients with 14 non-ATs (10 uncommon AVNRTs and 4 PJRTs). Age, sex, and AV Wenckebach rxr receptor length at baseline in the EP study were not significantly different between the 2
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Treatment administered thereafter involved approaches Becaus
2019-04-15
Treatment administered thereafter involved 2 approaches. Because the patient had LV dyssynchrony with LBBB, we planned to implant a biventricular pacing device. A CRT-D was chosen despite the absence of syncope and non-sustained ventricular tachycardia. The choice of the device was based on the pres
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br Conclusions br Study limitations br Conflict of
2019-04-15
Conclusions Study limitations Conflict of interest Introduction Dabigatran etexilate, an orally administered pro-drug, is rapidly converted by a serum esterase to dabigatran, a potent, direct, and competitive inhibitor of thrombin. It has an absolute bioavailability of 6.5% and a serum c
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Our results are consistent with previous findings in other m
2019-04-15
Our results are consistent with previous findings in other malignancies. Functional assays revealed that ectopic expression of UCA1 promoted cell proliferation and/or reduced cell apoptosis in non-small cell lung cancer [19], breast cancer [18], colorectal cancer [28], and renal cell carcinoma [23]
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Baseline WBC count and baseline measures
2019-04-15
Baseline WBC count and baseline measures of hepatic and renal function for responders and nonresponders are shown in Table 1. No relationship was evident between responders to decitabine or treatment choice and baseline WBC counts, or between responders and baseline measures of hepatic function (ALT
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br Discussion Sato et al first reported
2019-04-15
Discussion Sato et al. [11] first reported TCM in 1990, and thereafter, numerous cases were reported in the late 2000s. In 85% of the cases, TCM onset was preceded by an emotional or physical stress event, however, in 15% of the cases, the presence of a stress trigger could not be detected [2]. M
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There has been scant prior research focusing on
2019-04-15
There has been scant prior research focusing on the clinical efficiency and safety of either BV alone or in combination with chemotherapy in treating relapsed or refractory CD30+ T cell lymphoma, ALCL and HL. Although the most common and significant adverse events of BV, such as peripheral neuropath
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We have recently completed a
2019-04-11
We have recently completed a prospective randomized feasibility study of de-escalated bisphosphonate treatment with intravenous pamidronate in patients with metastatic breast cancer to bone [7]. Here we report on an analysis utilizing data from this trial aimed at comparing BPI and FACT-BP and to co
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A recent meta analysis has shown that an
2019-04-11
A recent meta-analysis has shown that an enlarged LA increases the risk of AF recurrence after a single CPVI, regardless of the follow-up duration [5]. This finding can be applied to paroxysmal and persistent AF [6,7]. In clinical practice, measurement of LAD can provide a window into the status of
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