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Fpr appears to be an indispensable
2021-10-18
Fpr2 appears to be an indispensable component of the signaling chain governing dendritic cell trafficking in allergic airway inflammation (Chen et al., 2010). The FPR3 agonist FL2 is chemoattractant for dendritic cells, but its biological role in vivo is yet to be defined. Within the inflammatory s
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Both anxiety like behavior and
2021-10-18
Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo
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br Acknowledgments We apologize to
2021-10-18
Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu
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Antigen presentation of incoming viral particles has been we
2021-10-18
Antigen presentation of incoming viral particles has been well studied for diverse viruses in antigen-presenting cells (APCs), mostly in dendritic cells and macrophages in the context of the exogenous antigens’ pathway to prime the CD8+ T cells. However, CD4+ T cells are not known as efficient APCs,
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The more important effect of pitolisant
2021-10-18
The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced Benzoylmesaconitine release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic
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ARCA Cy5 EGFP mRNA br Conclusion br Conflict of interest Ple
2021-10-18
Conclusion Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details. Exotic species such as hedgehogs are becoming popular companion animals. Therefore, they are more commonly seen in veterinary clinics. Acariasis is fairly common in these animals, us
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Platycodon grandiflorum is a member
2021-10-18
Platycodon grandiflorum is a member of the genus Platycodon and is commonly known as balloon flower. In East Asia, P. grandiflorum is used for the treatment of asthma, coughs, inflammatory diseases, pulmonary tuberculosis, and diabetes (Takagi and Lee, 1972). Furthermore, recent studies have reporte
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103 9 receptor Main Text There are over small GTPases that p
2021-10-18
Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, 103 9 receptor dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-bo
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br Consequence physiological function of
2021-10-18
Consequence/physiological function of ROS-dependent inhibition of GSNOR Plants response to environmental changes induced by abiotic and biotic factors by enhanced accumulation of ROS resulting in temporary imbalance of the cellular redox homeostasis. This as oxidative stress/burst termed event tr
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Various inhibitors have been developed
2021-10-18
Various inhibitors have been developed to target molecules present in these pathways. They include both man-made monoclonal sodium channel as well as small molecule membrane permeable inhibitors that often target kinases or phosphatases [5], [338], [348], [364]. In summary, these pathways are frequ
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A few of the islet specific proteins identified in the
2021-10-18
A few of the islet-specific proteins identified in the present study have previously been described in various contexts of pancreatic islets, i.e. PTPRN, SCG5, SCGN, SNAP25 and SNED1, validating the search algorithm applied and supporting the notion that also the novel proteins identified are indeed
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In this study three potential
2021-10-18
In this study, three potential Otx-2 tnf alpha inhibitor were found in the promoter region of the sheep GnRH gene: −1786 bp to −1770 bp, −825 bp to −819 bp, and − 529 bp to −523 bp. Combined with the results of the double-luciferase assay, it could be inferred that the binding site of Otx-2 in the
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To verify the feasibility of the proposed method
2021-10-18
To verify the feasibility of the proposed method, EIS is firstly adopted to study the modification processes of the electrode. As shown in Fig. 1A, the nyquist plot of bare gold electrode exhibits a straight line, which indicates a fast charge transfer process (curve a). After modified with probe a,
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In agreement with the results obtained from
2021-10-18
In agreement with the results obtained from GluR-A−/− mice, mice in which the NR1 subunit of the NMDA receptor has been selectively deleted from the CA3 subfield of the hippocampus displayed normal acquisition of the standard reference memory version of the watermaze task (Nakazawa et al., 2002), bu
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Apple juice is the most
2021-10-18
Apple juice is the most consumed apple derivative since more than 20% of freshly harvested apples are consumed as juice (Schulze et al., 2014). Apple juice production implies several technological interventions, among which are skin and pomace removal, enzymatic depectinization, and pasteurization.
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