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Previously we reported a chemical genetic screen that reveal
2018-11-12
Previously, we reported a chemical genetic screen that revealed that several statins activate a β-catenin-responsive luciferase reporter (BAR) in a cell-based assay (Biechele et al., 2010). This result supports prior in vitro studies that have shown that statins modulate Wnt/β-catenin signaling (hen
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LY2584702 Environmental oxygen levels affect tissue vascular
2018-11-12
Environmental oxygen levels affect tissue vascularization and fracture healing. A previous study suggested that hyperoxia (50% O2 and 1ATA) increased tissue vascularization but did not significantly alter osteogenesis during the early stages of fracture healing (Lu et al., 2013). Most of the inspire
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An important challenge to overcome
2018-11-12
An important challenge to overcome in developing a cell replacement therapy for hearing loss is the development of a functionally stable stem cell-derived neural population (Needham et al., 2013). This entails both the development of electrically active neurons and their functional integration inclu
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hexokinase inhibition We next aimed to test the differentiat
2018-11-12
We next aimed to test the differentiation capabilities of the EZ spheres. We found that at any passage for all cell lines regardless of cryopreservation, EZ spheres can be placed in specific neural induction media for terminal neuronal or glial cell differentiation using protocols adapted from those
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Taken together our findings support the hypothesis
2018-11-12
Taken together, our findings support the hypothesis that AM can rescue OPC differentiation via receptor-mediated Akt signaling. However, there are some important caveats to keep in mind. First, our current study used only a pure cell culture system. However, to prove clinically-relevant supportive/p
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fructose 1 6 bisphosphatase The PBMC iPS F cell
2018-11-12
The PBMC1-iPS4F1 cell line has been adapted to feeder-free culture conditions and displays a normal karyotype (46, XX) after extensive mechanical and enzymatic transfers (Fig. 1D). The iPSC line was also characterized using a genetic fingerprinting assay by microsatellite analysis. The endogenous e
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br Experimental Procedures br Author Contributions
2018-11-09
Experimental Procedures Author Contributions Acknowledgments Introduction Nuclear reprogramming of somatic ras gtpase using genetic modification and overexpression of pluripotent transcription factors is essential for creating induced pluripotent stem cells (iPSCs) in vitro (Takahashi a
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br Results br Discussion The
2018-11-09
Results Discussion The dataset allows a well-defined comparison of protein abundance and phosphorylation in pluripotent LDN193189 and the earliest definitive hNSCs. This contrasts with previous studies that used hESCs and heterogeneous mixtures of differentiated progeny (Brill et al., 2009; R
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br Introduction Embryonic stem cells
2018-11-09
Introduction Embryonic stem cells (ESCs) are self-renewing pluripotent cells, derived from the inner cell mass of Go 6983 (Smith, 2001). The transcriptional control of pluripotency is well characterized. Master transcription factors, such as Pou5f1 (Oct4), Sox2, and Nanog, maintain pluripotency
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br Experimental Procedures See Supplemental Experimental Pro
2018-11-09
Experimental Procedures See Supplemental Experimental Procedures for additional details. Author Contributions Acknowledgments Derivation and characterization of H1-ECs and RNA-seq experiments were supported by NIH in collaboration with the Defense Advanced Research Projects Agency and the
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Acceleration of neutrons in the uniform
2018-11-09
Acceleration of neutrons in the uniform magnetic field by means of a radio-frequency flipper is well known and successfully used in physical experiments (see, e.g., Ref. [7]). The phenomenon of neutron acceleration in a strong alternating magnetic field (of amplitude ∼0.4T) was observed in Ref. [8].
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These findings come from the discipline
2018-11-09
These findings come from the discipline of evolutionary psychology, which has also analyzed its subjects’ decision-making behaviour as neutrophil elastase inhibitor (Griskevicius & Kenrick, 2013), meaning their financial decisions and their choices about consumption, working on the principle that t
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Our recent review of the
2018-11-09
Our recent review of the literature revealed only two studies that evaluated coherence in ASD in the sleeping brain, and together, the studies included more adults than children. In 2010, Leveille et al. (Leveille et al., 2010) compared coherence during REM sleep between nine adults with ASD and 13
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br Methods br Results br
2018-11-09
Methods Results Discussion Monitoring and early prediction of patient response to therapy is increasingly important, particularly because of heterogeneity of response to expensive or toxic agents, and missed opportunity of effective therapy by early switching. Many drugs, although targeted
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Mechanistically we show that CRL CDT is the
2018-11-09
Mechanistically, we show that CRL4CDT2 is the primary target of inactivation by pevonedistat in melanoma and that its toxicity is dependent primarily on the stabilization of the CRL4CDT2 substrates SET8 and p21 both in vitro and in vivo. The lack of a therapeutic response on melanoma cells with hypo
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