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RG cells have been generated from a
2018-11-08
RG cells have been generated from a variety of different sources of embryonic and adult brains, and embryonic stem cells (Conti et al., 2005; Liour and Yu, 2003; Bibel et al., 2004; Malatesta et al., 2000). In addition to isolating RG cells from human fetal tissue (Mo et al., 2007), it has recently
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To date safety studies in humans do not have
2018-11-08
To date, safety studies in humans do not have extended follow-up in particular with respect to the evaluation of MSC tumorigenic potential. Investigations described in this review were certainly validated by institutional ethics committees; however, not only registered- and university affiliated-inv
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br Materials and methods br
2018-11-08
Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by 17 alpha hydroxylase that were not multipotent, based upon their differentiation capacity
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We chose to use the human GFAABC D promoter to
2018-11-08
We chose to use the human GFAABC1D promoter to drive TagRFP in human astrocytes because of its accuracy to specifically direct reporter expression in astrocytes in several CNS regions, at embryonic and adult stage, in rodent (Lee et al., 2008). Interestingly, during the pre-screening stage, at 70 DI
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In our prior studies we showed that K
2018-11-08
In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer Digoxigenin-11-ddUTP through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG12D promote
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somatostatin receptor The identification of stem cells or pr
2018-11-08
The identification of stem somatostatin receptor or progenitor cells, and their contribution to pancreatic regeneration remain controversial (Ziv et al., 2013; Burke and Tosh, 2012). The pancreas uses several regenerative mechanisms. Self-renewal is the principal mechanism of acinar and islet regen
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After comparing the lymph angiogenic effects of HLE and HLF
2018-11-08
After comparing the (lymph)angiogenic effects of HLE and HLF, UVB-induced changes in their protein expression patterns were also assessed. As shown by the protein array assessment, following UVB irradiation of HLF national prevalence amphiregulin, uPA (a strong promoter of angiogenesis (Oh et al.,
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Similar to our in vitro results
2018-11-08
Similar to our in vitro results, transplanted iNSCs exhibited in vivo-characteristics, transcriptome profiles, neural and metabolic programs similar to those of transplanted NSCs. In contrast to engrafted forebrain NSCs, however, transplanted iNSCs strongly expressed caudal regional marker genes and
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To confirm the pluripotency of the MIXL eGFP
2018-11-08
To confirm the pluripotency of the MIXL1-eGFP hESCs, the expression of several pluripotency markers was analyzed by quantitative real-time PCR as well as immunocytochemsitry. Endogenous expression of NANOG, OCT4 and SOX2 was determined at the mRNA level by real-time PCR (Fig. 1C). Protein expression
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Unfortunately exploration of the biochemical
2018-11-08
Unfortunately, exploration of the biochemical mechanisms that underlie germ cell specification and early PGC formation in the mammalian embryo is hampered by the scarcity of neutrophil elastase inhibitor at these early embryonic time points. In vitro derivation of PGCs from embryonic stem cells (ES
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Following fundamental analysis of pharmacological
2018-11-08
Following fundamental analysis of pharmacological and electrophysiological features of suspension-derived CMs, we have demonstrated direct applicability of bioreactor-produced EBs for tissue engineering. While BCT generation from undissociated, contracting spheres was recently shown, this required g
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Partial cleavage of CXCL at the N
2018-11-08
Partial cleavage of CXCL12 at the N-terminus by distinct peptidases results in loss of chemotactic activity and impairment in CXCR4 receptor affinity (Cho et al., 2010; Delgado et al., 2001; Levesque et al., 2003). The proteolytic cleavage of CXCL12 by matrix metalloproteinase 2 and 9 (MMP-2 and 9)
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These fate analyses relied on the restriction of
2018-11-08
These fate analyses relied on the restriction of Krox20 expression to BC p450 inhibitors during early PNS development. However, from embryonic day 15.5 (E15.5), Krox20 also is expressed in Schwann cells (Topilko et al., 1994), thereby preventing later analysis of BC derivatives. To circumvent this
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Another important finding in this
2018-11-07
Another important finding in this study is that REMSD was able to induce remarkable anxiolytic-like effects similar to 8-M-PDOT. This outcome becomes evident due to the ceiling effect induced by REMSD (Fig. 2E). However, these results cannot be interpreted as a merely consequence of an alteration in
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purchase EHT 1864 From studies with mouse models Huber Lang
2018-11-07
From studies with mouse models (Huber-Lang et al., 2006; Hoth et al., 2014; Khan et al., 2013; Auger et al., 2012; Zecher et al., 2014; Borkowska et al., 2014), several groups have concluded that thrombin is the major coagulation enzyme that generates C5a under pathologic conditions. This role for t
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