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br Materials and methods br
2024-04-26
Materials and methods Results and discussion Conclusion Amino-functionalized mesoporous TiO2-NH2 microparticles were used to immobilize ADA, followed by GLU cross-linking. The mesopores provided a natural microenvironment with sufficient room for the enzyme to efficiently perform its cataly
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Sperm total motility and hyperactivated motility are
2024-04-26
Sperm total motility and hyperactivated motility are mediated by PLD-dependent bimatoprost australia polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrating low motility c
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Plant material and growth conditions
2024-04-26
Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark Alfacalcidol synthesis in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning and plant trans
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In order to improve the methodology of the synthesis of
2024-04-26
In order to improve the methodology of the synthesis of steroidal derivatives, our goal was the investigation of aza-Michael addition of different N-nucleophiles to 16-dehydropregnenolone in the presence of [DBU][OAc] as catalyst and reaction medium. Michael addition of electron deficient steroidal
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The synthesis and secretion of adrenal androgens is apparent
2024-04-26
The synthesis and secretion of adrenal androgens is apparently unique to humans and nonhuman primates, and requires the expression of key mediators such as CYP17 [26]. Endocrine control of CYP17 expression in rhesus monkeys is comparable to that in humans [27]. An analysis of baboon cDNA for CYP17 s
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br Role of autophagy in alcoholic cardiomyopathy br Concludi
2024-04-26
Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa
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Jesus et al discovered a new series
2024-04-26
Jesus et al. discovered a new series of azaindole as Aurora inhibitors through various modification of GSK1070916 (47). They synthesized series from modification of the GSK1070916 and evaluated for in-vitro Aurora-B/INCENP and Aurora-A/TPX2 inhibition assays. Modified inhibitor of apoptosis 48 and 4
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These results must also be addressed in light of
2024-04-26
These results must also be addressed in light of porcine AMPKγ3R200Q (RN−) mutation. Pigs harboring this mutation produce meat with an abnormally low ultimate pH (pHas WZ4003 synthesis meat (Copenhafer et al., 2006, Lundström et al., 1998, Milan et al., 2000). This extremely low pH is very close to
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histamine-2 receptor antagonist To maintain ATP levels postm
2024-04-26
To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield histamine-2 receptor antagonist 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (P & Honikel, 1973). Similar to PFK-1, however, the activity
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Given the recent discovery of regions of single
2024-04-26
Given the recent discovery of regions of single-stranded DNA in the nuclei of hypoxic cells, the role for ATR in the response to hypoxic stress seems clearer . Zou and Elledge demonstrated that both Ddc 2 (the homolog of ATRIP) and ATRIP have a lower affinity for double-strand breaks than they do f
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ASK has been identified as an ASK binding protein Wang
2024-04-26
ASK2 has been identified as an ASK1 binding protein (Wang et al., 1998). ASK1 supports the stability and active configuration of ASK2 in the heteromeric complex, while ASK2 has been found to activate ASK1 by direct phosphorylation (Takeda et al., 2007). Unlike ASK1, which is ubiquitously expressed i
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br Declaration of interest br
2024-04-26
Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers
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Enhanced arginase activity and the resultant decreases in L
2024-04-26
Enhanced arginase activity and the resultant decreases in L-arginine levels can also impair T cell mediated immune function and allow tumor growth by limiting the supply of L-arginine needed for the formation of cytotoxic levels of NO by iNOS [10]. Increased arginase expression/activity may also lim
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Therefore in the present study we first examined the
2024-04-26
Therefore, in the present study, we first examined the ATRAP droperidol in human leukocytes of healthy subjects. We next analyzed possible relevant clinical factors affecting ATRAP expression in leukocytes of patients with NCDs. Furthermore, we examined the possible effect of ATRAP downregulation on
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PD 0332991 br Experimental procedures br Results br Discussi
2024-04-26
Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific